Invincibility and shields will not trigger a sacrifice (including Holy Mantle).Dying in a sacrifice room while holding Missing Poster will unlock The Lost.The Dark Room teleport still happens on any floor even if you haven't unlocked it yet.The sacrifice room door stays open during the Angel fights, meaning they can be skipped to proceed to the next level of sacrificing without killing them.A payout is randomly chosen from each of the possible ones for that sacrifice.The 'You feel blessed!' buffs can even allow an Angel Room to spawn after taking a Devil Deal.Teleport directly to the Dark Room floor (50% chance)Ī big thank you to Zamie who did the research and added the above stats to the Sacrifice Room Wiki page.Gabriel Angel mini-boss spawns (100% chance).It brings a staggering 102 new challenges to the game, testing player skills on any number of fronts, including using certain items, killing certain enemies, overcoming different.
The below table details each level of payout and the reward for reaching each tier: Number of Sacrifices The Sacrifice Room now has various different levels of rewards, depending on the amount of times used on the same floor. Historically, Sacrifice Rooms have always been pretty darn useless in The Binding of Isaac, but lucky owners of the Afterbirth DLC will find they've had a huge revamp, significantly increasing the quality of rewards you can find.